Surfing the MASH Tsunami

S3-E38.4 - From the Vault: NITs & Advancing NASH Therapy at AASLD 2021

July 30, 2022 HEP Dynamics LLC Season 3 Episode 38
Surfing the MASH Tsunami
S3-E38.4 - From the Vault: NITs & Advancing NASH Therapy at AASLD 2021
Show Notes

Our week of "Greatest Hits" episodes from the vault continues with our second most popular conversation ever, which came from the wrap-up episode for AASLD2021. In this episode, Manal Abdelmalek, Jörn Schattenberg and Ian Rowe joined Stephen Harrison, Louise Campbell and Roger Green to recap NAFLD and NASH-related insights from AASLD2021 TLMdX and specifically to focus on how NITs will help, in the words of Stephen Harrison, "put a big, fat dent in Fatty Liver disease."

As I wrote at the time: The conversation starts with the group congratulating Manal Abdelmalek on her wrap-up NAFLD talk at the 2021 TLMdX. From there, the group focuses on the shortcomings of using biopsy as the clinical trial gold standard and how strategic clinical trial design and interpretation of existing NIT data can build a bridge from biopsy through MRE/biopsy correlations to a total NIT future.