Surfing the NASH Tsunami

Wild Times in NASH-Ville Part 3: Better Days ARE Ahead! Ep 28

September 30, 2020 HEP Dynamics LLC Season 1 Episode 28
Surfing the NASH Tsunami
Wild Times in NASH-Ville Part 3: Better Days ARE Ahead! Ep 28
Chapters
Surfing the NASH Tsunami
Wild Times in NASH-Ville Part 3: Better Days ARE Ahead! Ep 28
Sep 30, 2020 Season 1 Episode 28
HEP Dynamics LLC

Stephen Harrison leads the Surfers through a review of FGF-21s and other exciting drug development news.

Stephen Harrison starts this week's discussion reviewing the recent announcement of a promising Phase 1b/2a study for 89bio-100 (link to slide deck below), an FGF-21 agent that demonstrated significant reductions on liver fat and had positive effects on other metabolic measures. The discussion broadened to address an array of issues: other agents in development; changing (higher) expectations for how these agents will affect PDFF and possibly fibrosis; possible directions for combination therapy; and the five clinical values that collectively tell us the impact new medications can have on overall liver and metabolic health. One Surfer described this as a "brilliant 20-minute review." 

89bio-slide deck: http://bit.ly/89bio-report

Show Notes

Stephen Harrison leads the Surfers through a review of FGF-21s and other exciting drug development news.

Stephen Harrison starts this week's discussion reviewing the recent announcement of a promising Phase 1b/2a study for 89bio-100 (link to slide deck below), an FGF-21 agent that demonstrated significant reductions on liver fat and had positive effects on other metabolic measures. The discussion broadened to address an array of issues: other agents in development; changing (higher) expectations for how these agents will affect PDFF and possibly fibrosis; possible directions for combination therapy; and the five clinical values that collectively tell us the impact new medications can have on overall liver and metabolic health. One Surfer described this as a "brilliant 20-minute review." 

89bio-slide deck: http://bit.ly/89bio-report